A group of 86 persons (65 women, 21 men) working at the risk of ionizing radiation (IR) was examined for the levels of alpha 2-macroglobulin ( α2-M),. Buy A2M reference serum, Alpha 2-Macroglobulin (A2M) Reference Standard Reference Serum-NP000005.2 (MBS563285) product datasheet at MyBioSource.
![]() Alpha 2 Macroglobulin Serum Test
Native Human Alpha 2 Macroglobulin
Alpha 2 macroglobulin, also known as α2-macroglobulin and abbreviated as α2M and A2M, is a tetrameric glycoprotein produced in the liver and found in blood. It is involved in proteinase inhibition via a unique 'trapping' mechanism.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Product Specific References![]() Alpha-2-macroglobulin InflammationReferences for Alpha 2 Macroglobulin
Alpha-2-macroglobulin is a protease inhibitor and is 1 of the largest plasma proteins. It transports hormones and enzymes, exhibits effector and inhibitor functions in the development of the lymphatic system, and inhibits components of the complement system and hemostasis system.
Increased levels of alpha-2-macroglobulin are found in nephrotic syndrome when other lower molecular weight proteins are lost and alpha-2-macroglobulin is retained because of its large size. In patients with liver cirrhosis and diabetes, the levels are found to be elevated.
Alpha-2-macroglobulin Function
Patients with acute pancreatitis exhibit low serum concentrations which correlate with the severity of the disease. In hyperfibrinolytic states, after major surgery, in septicemia and severe hepatic insufficiency, the measured levels of alpha-2-macroglobulin are often low. Acute myocardial infarction patients with low alpha-2-macroglobulin have been reported to have a significantly better prognosis with regard to the greater than a year survival time.
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